Biologics PA are far more complex than PA for standard medications. Payers typically require step-therapy history, recent labs or imaging, and weight-based dosing details before approval. Some biologics run through the pharmacy benefit (self-injectables), while many are billed under the medical benefit (infusions), forcing clinics to navigate through separate portals. Because of these stricter requirements, biologic prior authorizations see much higher denial and delay rates than traditional drug PAs — adding significant burden for providers and patients.